منابع مشابه
Axon guidance: Crossing the midline
Neurons that connect the two sides of the nervous system project their axons across the midline. New studies provide evidence for a conserved gatekeeping mechanism that controls this midline crossing.
متن کاملLola regulates midline crossing
In each hemisegment of the developing Drosophila ventral nerve cord, the axons of ~20% of the 350 or so embryonic interneurons grow longitudinally on the same side of the midline where their cell bodies lie; they never cross the midline of the CNS (Schmid et al., 1999). In part, this pattern of axon growth reflects the existence of molecular forces that repel axons away from the midline (Klambt...
متن کاملRadiolucency of anterior mandible crossing midline
Odontogenic cysts are the most commonly occurring cysts in the jaws and are the reason for the radiolucent appearances. The radicular cyst is a type of an infl ammatory cyst, caused due to pulpal necrosis followed by trauma or caries, with an associated infl ammatory response at the periapical region. Many a times it is diffi cult to diff erentiate from other bony lesions and it poses diagnosti...
متن کاملcAMP Promotes Retinal Midline Crossing at the Zebrafish Optic Chiasm
During development, axons navigate a complex intracellular milieu, often over long distances to reach target tissues at stereotyped locations. The basis for this navigation lies in the growth cone a motile structure at the tip of the growing axon. Studded with receptors for an array of guidance cues, the growth cone interprets a balance of attractive and repellant signals en route to its target...
متن کاملCrossing the Midline Roles and Regulation of Robo Receptors
In the Drosophila CNS, the midline repellent Slit acts at short range through its receptor Robo to control midline crossing. Longitudinal axons express high levels of Robo and avoid the midline; commissural axons that cross the midline express only low levels of Robo. Robo levels are in turn regulated by Comm. Here, we show that the Slit receptors Robo2 and Robo3 ensure the fidelity of this cro...
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ژورنال
عنوان ژورنال: Neuron
سال: 2000
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)00152-5